#6200. Highly controlled robotic customized gel functionalization on 3D printed PCL framework for bone tissue engineering

September 2026publication date
Proposal available till 13-05-2025
4 total number of authors per manuscript0 $

The title of the journal is available only for the authors who have already paid for
Journal’s subject area:
Computer Science Applications;
Biotechnology;
Biomedical Engineering;
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Abstract:
Despite their natural healing capacity, bone tissues face ample challenges during healing and reconstruction, especially when healing critical-size defects. 3D printing with thermoplastic bioresorbable materials offers great potential to develop patient-specific bone grafts but these are hydrophobic in nature and lead to poor implant-tissue integration. Therefore, this work aims to fabricate a patient-specific 3D printed, strong, macroporous, PCL core framework of a desired shape surrounded by a highly bioactive, open-cell, soft, microporous gel coating. A novel easy-to-reproduce robotic gel coating methodology is demonstrated to achieve a highly controlled customized gel coating that partially or totally fills the 3D printed pores or provides a thin layer over the PCL surface, and is optimised here for the best in vitro results.
Keywords:
3D printing; Bone; Composite scaffold; Gel coating; Hydrogel; Multiscale porosity; Patient-specific; Polycaprolactone; Robotic dip coating

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