#9714. Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring

August 2026publication date
Proposal available till 16-05-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Environmental Science (miscellaneous);
Social Psychology;
Genetics;
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Abstract:
Background: Gene mutations induced in germ cells may be transmitted to the next generation and cause adverse effects such as genetic diseases. Certain mutations may result in infertility or death in early development. Thus, the mutations may not be inheritable. However, the extent to which point mutations in male germ cells are transmitted to the next generation or eliminated during transmission is largely unknown. This study compared mutation frequencies (MFs) in sperm of N-ethyl-N-nitrosourea (ENU)-treated gpt delta mice and de novo MFs in the whole exome/genome of their offspring.
Keywords:
de novo mutation; Germline mutation; gpt delta transgenic mouse; Mutation frequency; Whole genome sequencing

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