#8167. Determining reliable parameter estimates for within-host and within-vector models of Zika virus

October 2026publication date
Proposal available till 08-06-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Ecology;
Ecology, Evolution, Behavior and Systematics;
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Abstract:
In this paper, we introduce three within-host and one within-vector models of Zika virus. The within-host models are the target cell limited model, the target cell limited model with natural killer (NK) cells class, and a within-host-within-fetus model of a pregnant individual. The within-vector model includes the Zika virus dynamics in the midgut and salivary glands. The within-host models are not structurally identifiable with respect to data on viral load and NK cell counts. After rescaling, the scaled within-host models are locally structurally identifiable. The within-vector model is structurally identifiable with respect to viremia data in the midgut and salivary glands.
Keywords:
immune dynamics; parameter estimation; structural and practical identifiability; Zika virus; Zika within-host models; Zika within-vector model

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