#11639. Role of molecular techniques in PMI estimation: An update

August 2026publication date
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Journal’s subject area:
Law;
Pathology and Forensic Medicine;
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More details about the manuscript: Science Citation Index Expanded or/and Social Sciences Citation Index
Abstract:
The time frames between death and reporting of the cadaver, known as post Mortem interval (PMI), is essential in investigation of homicide deaths, suspicious deaths, or other untimely deaths as well as natural deaths. Over the time several methods are developed which depends upon factors as several methods physiological, biochemical, entomological, and archaeological for the estimation of degradation of body with time. Hence, we still need new methods for better estimation of PMI. With the advent of the field of molecular biology, the estimation of PMI is proposed to be executed by evaluating the degradation pattern of the biological markers (DNA, RNA, and Proteins). It is now proved that the DNA is fairly unwavering over long post-mortem phases, RNA is much more labile in nature, and sensitive to degradation in a tissue-specific manner. Thus, the main purpose (aim, agenda) of this document is to provide review that mainly focuses on potential use of RNA markers in estimation of PMI. For this Critical Review, the systematic evaluation of 47 studies is executed according to the chosen inclusion and exclusion criteria.
Keywords:
Biological markers; Forensic genetics; Molecular biology; PMI estimation; qRT-PCR; RNA

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