#9716. Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments

September 2026publication date
Proposal available till 16-05-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Environmental Science (miscellaneous);
Social Psychology;
Genetics;
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Abstract:
Objectives: To explore the role of folate metabolism in 1,3-Butadiene (BD)s genotoxicity, we conducted a match-up study in BD-exposed workers in China to analyze the associations between the polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and the chromosomal damage induced by BD exposure, and culture-based experiments in TK-6 cells to examine the global DNA methylation levels and chromosomal damage when exposed both to BD’s genotoxic metabolite, 1,2:3,4-diepoxybutane (DEB), and MTHFR’s direct catalytic product, 5-methyltetrahydrofolate (5-MTHF). Methods: Cytokinesis block micronucleus assay (CBMN) was used to examine the chromosomal damage induced by BD or DEB. Poisson regression models were produced to quantify the relationship of chromosomal damage and genetic polymorphisms in the BD-exposed workers. Global DNA methylation levels in TK6 cells were examined using DNA Methylation Quantification Kit.
Keywords:
1,3-butadiene; Chromosomal damage; Folate metabolism; MTHFR; Polymorphism

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