#9643. The role of the cingulate cortex in the generation of motor tics and the experience of the premonitory urge-to-tic in Tourette syndrome

September 2026publication date
Proposal available till 15-05-2025
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Journal’s subject area:
Neuropsychology and Physiological Psychology;
Behavioral Neuroscience;
Cognitive Neuroscience;
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Abstract:
Tourette syndrome (TS) is a neurological disorder of childhood onset that is characterized by the occurrence of motor and vocal tics. TS is associated with cortical-striatal-thalamic-cortical circuit [CSTC] dysfunction and hyper-excitability of cortical limbic and motor regions that are thought to lead to the occurrence of tics. Individuals with TS often report that their tics are preceded by ‘premonitory sensory/urge phenomena’ (PU) that are described as uncomfortable bodily sensations that precede the execution of a tic and are experienced as a strong urge for motor discharge. While the precise role played by PU in the occurrence of tics is largely unknown, they are nonetheless of considerable theoretical and clinical importance as they form a core component of many behavioural therapies used in the treatment of tic disorders.
Keywords:
cingulate cortex; premonitory urge; structural covariance networks; tics; Tourette syndrome; voxel-based morphometry

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