#9623. The impact of methamphetamine/amphetamine use on receipt and outcomes of medications for opioid use disorder: a systematic review

September 2026publication date
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Journal’s subject area:
Pharmacology
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Abstract:
Background: Methamphetamine/amphetamine use has sharply increased among people with opioid use disorder (OUD). It is therefore important to understand whether and how use of these substances may impact receipt of, and outcomes associated with, medications for OUD (MOUD). This systematic review identified studies that examined associations between methamphetamine/amphetamine use or use disorder and 3 classes of outcomes: (1) receipt of MOUD, (2) retention in MOUD, and (3) opioid abstinence during MOUD.
Keywords:
Amphetamine; Buprenorphine; Methadone; Methamphetamine; Naltrexone; Opioid agonist; Opioid use disorder; Polysubstance use

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