#9356. Roles of corticotropin-releasing factor signaling in the lateral habenula in anxiety-like and alcohol drinking behaviors in male rats

November 2026publication date
Proposal available till 18-05-2025
4 total number of authors per manuscript5500 $

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Journal’s subject area:
Psychiatry and Mental Health;
Neuropsychology and Physiological Psychology;
Behavioral Neuroscience;
Physiology;
Endocrine and Autonomic Systems;
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Abstract:
Corticotropin-releasing factor (CRF) signaling in the mesocorticolimbic system is known to modulate anxiety-like behavior and alcohol consumption, behaviors that also have been associated with the hyper-glutamatergic state of the lateral habenula (LHb) neurons in rats. However, the role of CRF signaling in the LHb on the glutamate transmission, anxiety-like behaviors and alcohol consumption is unknown. Here, we used male rats that had been consuming alcohol for three months to address this gap in the literature.
Keywords:
CRF receptors; Ethanol withdrawal; Glutamate; Lateral habenula; Stress

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