#9321. Anterior thalamic NMDA-induced damage impairs extrapolation relying on serial stimulus patterns, in rats

November 2026publication date
Proposal available till 17-05-2025
4 total number of authors per manuscript6020 $

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Journal’s subject area:
Experimental and Cognitive Psychology;
Behavioral Neuroscience;
Cognitive Neuroscience;
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Abstract:
Extrapolation of serial stimulus patterns seems to depend upon identification and application of patterns relating sequences of stimuli stored in memory, thus allowing prediction of pending events never experienced before. There have been proposals that such a “generator of predictions system” would include the subiculum, mammillary bodies, anteroventral thalamus and cingulate cortex (e.g., Gray, 1982). The anteroventral thalamus (AVT) seems to be in a strategic position, both hodologically and experimentally, to allow testing of this hypothesis. This study investigated the effect of NMDA-induced damage to the anteroventral thalamus [part of the anterodorsal (AD) thalamus was also damaged in some animals], following stereotaxic minute topic microinjections, on the ability of male Wistar rats to extrapolate relying on serial stimulus patterns.
Keywords:
Anticipatory Behavior; Generator of Predictions System; Septo-hippocampal System

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