#9168. Morphine exposure alters Fos expression in a sex-, age-, and brain region-specific manner during adolescence

September 2026publication date
Proposal available till 11-05-2025
4 total number of authors per manuscript4500 $

The title of the journal is available only for the authors who have already paid for
Journal’s subject area:
Developmental and Educational Psychology;
Behavioral Neuroscience;
Developmental Biology;
Developmental Neuroscience;
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Abstract:
Data in both humans and preclinical animal models clearly indicate drug exposure during adolescence, when the “reward” circuitry of the brain develops, increases the risk of substance use and other mental health disorders later in life. Human data indicate that different neural and behavioral sequelae can be observed in early versus late adolescence. However, most studies with rodent models examine a single adolescent age compared to a mature adult age, and often only in males. Herein, we sought to determine whether the acute response to the opioid morphine would also differ across adolescence, and by sex.
Keywords:
adolescent; morphine; nucleus accumbens; prefrontal cortex; sex difference

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