#9155. How rare and common risk variation jointly affect liability for autism spectrum disorder

August 2026publication date
Proposal available till 26-05-2025
4 total number of authors per manuscript3510 $

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Journal’s subject area:
Developmental and Educational Psychology;
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Abstract:
Genetic studies have implicated rare and common variations in liability for autism spectrum disorder (ASD). Of the discovered risk variants, those rare in the population invariably have large impact on liability, while common variants have small effects. Yet, collectively, common risk variants account for the majority of population-level variability. How these rare and common risk variants jointly affect liability for individuals requires further study.
Keywords:
Autism spectrum disorder; De novo mutation; Genomic-Best Linear Unbiased Prediction (G-BLUP); Liability; Polygenic risk score

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