#8660. Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells

November 2026publication date
Proposal available till 30-05-2025
4 total number of authors per manuscript3510 $

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Journal’s subject area:
Medicine (miscellaneous);
Biomedical Engineering;
Developmental Biology;
Cell Biology;
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Abstract:
Herein, we report the establishment of a human congenital cataract in vitro model through differentiation of patient-specific induced pluripotent stem cells (iPSCs) into regenerated lenses. Taken together, the in vitro model described herein, which recapitulates patient-specific clinical manifestations of congenital cataracts and protein aggregation in patient-specific LBs, provides a robust system for research on the pathological mechanisms of cataracts and screening of drug candidates for cataract treatment.
Keywords:
Lens diseases, Experimental models of disease, Stem-cell research

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