#8659. Metformin accelerates zebrafish heart regeneration by inducing autophagy

November 2026publication date
Proposal available till 30-05-2025
4 total number of authors per manuscript3510 $

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Journal’s subject area:
Medicine (miscellaneous);
Biomedical Engineering;
Developmental Biology;
Cell Biology;
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Abstract:
Here, we used an adult zebrafish model of heart cryoinjury, which mimics myocardial infarction in humans, and demonstrated that autophagy was significantly induced in the injured area. Metformin enhanced the autophagic flux and improved epicardial, endocardial and vascular endothelial regeneration, accelerated transient collagen deposition and resolution, and induced cardiomyocyte proliferation. Taken together, our results suggest that metformin has clinical value for the prevention of myocardial infarction.
Keywords:
Metformin; heart regeneration; autophagy; myocardial infarction; clinical value

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