#8580. Characteristics and clinical potential of a cellularly modified gelatin sponge

December 2026publication date
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Journal’s subject area:
Medicine (all);
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Abstract:
The aim of the study is to test a cellularly modified gelatin sponge as a scaffold for implanting human umbilical cord mesenchymal stem cells (HuMSCs). For this, HuMSCs were isolated, expanded and seeded in a poly-L-lysine (PLL)-coated gelatin sponge. The cell embedded gelatin sponges were implanted subcutaneously on the backs of mice and the samples were harvested and studied histologically. Gelatin sponge is a clinically accessible scaffold for HuMSCs implantation to maintain short-term survival of the cells and high-level production of growth factors, which demonstrates good clinical potential for enhancing wound healing.
Keywords:
3D culture; gelatin sponge; Mesenchymal stem cells; scaffold

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