#8579. In vivo MRI detection of intraplaque macrophages with biocompatible silica-coated iron oxide nanoparticles in murine atherosclerosis

November 2026publication date
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Journal’s subject area:
Medicine (all);
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Abstract:
We investigated the feasibility of synthesized silica-coated iron oxide nanoparticles (SIONs) coated with rhodamine B isothiocyanate and polyethylene glycol in the detection of macrophages in inflamed atherosclerotic plaques. The results demonstrate that polyethylene glycosylated SIONs could be a highly effective method to identify macrophage activity in atherosclerotic plaques as a multimodal imaging agent.
Keywords:
atherosclerosis; macrophage; magnetic resonance imaging; Nanoparticle

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