#8545. Ginsenoside Rg1 attenuates LPS-induced cognitive impairments and neuroinflammation by inhibiting NOX2 and Ca2+–CN–NFAT1 signaling in mice

November 2026publication date
Proposal available till 30-05-2025
4 total number of authors per manuscript3510 $

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Journal’s subject area:
Food Science;
Medicine (miscellaneous);
Nutrition and Dietetics;
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Abstract:
We study the protective effect of Rg1 in neuroinflammation induced by the lipopolysaccharide (LPS) challenge. The exposure to LPS for 14 days significantly induces cognitive impairment and causes the activation of NLRP1 inflammasome. Treatment with Rg1 significantly improved cognitive impairment and inhibited the activation of NLRP1 inflammasome.
Keywords:
Calcium homeostasis; Ginsenoside Rg1; Lipopolysaccharide; Neurodegenerative disease; NLRP1 inflammasome

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