#8441. Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models

November 2026publication date
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Medicine (all);
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Abstract:
We combine the advantages of adapted, transgenic animal models with a high-throughput procedure and 3R principles to investigate oncogenic driver mutations.Oncogenes representing the most important driver mutations in the airway system, both human and Drosophila orthologs, were ectopically expressed. Drosophila models can be used in a straight-forward high-throughput screening approach and can replace mouse models to a considerable extent.
Keywords:
oncology; oncogenes; driver mutations; lung cancer

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