#8438. Modular micro-physiological human tumor/tissue models based on decellularized tissue for improved preclinical testing

September 2026publication date
Proposal available till 30-05-2025
5 total number of authors per manuscript4030 $

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Journal’s subject area:
Medicine (all);
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Abstract:
This study presents 3D tumor models with tissue-like features for preclinical testing. 3D models on a decellularized tissue matrix show better predictivity and higher chemoresistance compared to 2D models. The matrix provides different niches for cell growth: on top as monolayer, in crypts as aggregates, and within deeper layers. Dynamic culture in bioreactors enhances cell growth. Comparing gene expression between 2D and 3D cultures, we observed changes related to proliferation, apoptosis and stemness.
Keywords:
oncology; cancer; preclinical models; decellularized tissue matrix; modular approach; 2D and 3D cultures

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