#8433. Hypermethylation of the OPRM1 and ALDH2 promoter regions in Chinese Han males with alcohol use disorder in Yunnan Province

December 2026publication date
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4 total number of authors per manuscript5500 $

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Journal’s subject area:
Clinical Psychology;
Psychiatry and Mental Health;
Medicine (miscellaneous);
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Abstract:
The study seeks to investigate whether DNA methylation of the OPRM1 and ALDH2 promoters are associated with alcohol sensitivity in men. For this, the bisulfite pyrosequencing method was used. We also extablished factors affecting the DNA methylation levels, particularly smoking. Age had no significant effect.
Keywords:
Alcohol use disorder; ALDH2; DNA methylation; OPRM1

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