#8423. A randomised, double-blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine

September 2026publication date
Proposal available till 29-05-2025
4 total number of authors per manuscript3510 $

The title of the journal is available only for the authors who have already paid for
Journal’s subject area:
Psychiatry and Mental Health;
Medicine (miscellaneous);
Pharmacology;
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Abstract:
Examining physically healthy participants with and without a history of childhood trauma,we investigated whether there is a connection between a history of adverse experiences during childhood and the feeling of pleasure from opioid use. Participants were given either an intramuscular active dose of opioid (0.15 mg/kg) or a very low dose control (0.01 mg/kg) to determine their physical pain threshold and tolerance pre- and post-drug administration. Childhood trauma was reported to sensitise individuals to the pleasurable and motivational effects of opioids and reduce sensitivity to the negative effects.
Keywords:
childhood adversity; childhood trauma; morphine; opioids; pain; reward

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