#8422. Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges

November 2026publication date
Proposal available till 29-05-2025
4 total number of authors per manuscript5500 $

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Journal’s subject area:
Psychiatry and Mental Health;
Medicine (miscellaneous);
Pharmacology;
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Abstract:
Chronic alcohol use leads to gene and miRNA expression changes across the mesocorticolimbic (MCL) system.We show that in subjects with alcohol dependence, circular RNAs (circRNAs) impact mRNA expression by interacting with miRNA in the nucleus accumbens. The study provides indirect evidence for the clinical importance of circRNA in the development of alcohol dependence by detecting a significant enrichment of circRNA expression quantitative trait loci among the genome-wide association studies of substance abuse.
Keywords:
alcohol; circular RNA; eQTL; gene expression; miRNA sponges; postmortem brain

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