#8368. Wheel running leads to sex-specific effects on Western diet-associated glucose homeostasis and brain insulin signaling without altering food-related impulsive choice

August 2026publication date
Proposal available till 10-05-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Medicine (miscellaneous);
Nutrition and Dietetics;
Neuroscience (all);
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Abstract:
Objectives: There is a clear association between obesity and impulsivity. While exercise can suppress weight gain and decrease impulsive choice (IC), the relationship between impulsivity, the consumption of palatable, energy dense diets, and exercise is unclear. We examined IC before and after Western diet (WD) exposure in rats of both sexes and whether exercise would rescue any diet-mediated increases in IC. Our hypotheses were twofold: first, increased impulsivity would be associated with higher WD preference in a positive feedback loop and second, increased WD consumption would impair both peripheral and central insulin signaling, both of which exercise would attenuate. Methods: Following baseline assessment of IC through a delay discounting task, rats were divided into na?ve, sedentary (Sed), or wheel running (WR) groups for a 5-week WR and two-diet choice period after which rats underwent an oral glucose (OGTT) and insulin tolerance test (ITT) in addition to a re-test of IC. Insulin induced Akt-GSK3? signaling in the brain was examined using western blot.
Keywords:
impulsive choice; insulin signaling; insulin tolerance test; oral glucose tolerance test; sex differences; Western diet; Wheel running

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