#8319. Association of serum uric acid with biventricular myocardial dysfunction in patients with type 2 diabetes mellitus

October 2026publication date
Proposal available till 08-06-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Cardiology and Cardiovascular Medicine;
Medicine (miscellaneous);
Endocrinology, Diabetes and Metabolism;
Nutrition and Dietetics;
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Abstract:
Background and aims: Increased serum uric acid (SUA) is common in type 2 diabetes mellitus (T2DM) and is associated with left ventricular (LV) myocardial dysfunction. Nonetheless the association of SUA with right ventricular (RV) function in T2DM has not been studied. This study aimed to investigate the association of SUA with biventricular myocardial function in patients with T2DM. Methods and results: A total of 560 patients with T2DM were enrolled and divided into four groups according to sex-specific quartiles of SUA. Transthoracic echocardiography was performed and two-dimensional speckle tracking was used to measure biventricular myocardial strain, including LV global longitudinal strain (GLS), circumferential strain (CS), radial strain (RS), and RV free wall longitudinal strain (RV-FWLS). The absolute value of all biventricular strain parameters showed a stepwise decrease across SUA quartiles (all P < 0.01).
Keywords:
Left ventricular function; Right ventricular function; Serum uric acid; Type 2 diabetic mellitus

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