#7918. Synthesis of drynaran and analogues

October 2026publication date
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Architecture;
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Safety, Risk, Reliability and Quality;
Civil and Structural Engineering;
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Abstract:
In a previous work, the natural compound drynaran, namely E-3-(5-hydroxymethyl)furan-2-yl)-2-phenylacrylaldehyde, was isolated from the Asian medicinal plant Drynaria bonii. Although this plant is used for several therapeutic purposes, drynaran was isolated in small quantities and, therefore, evaluated only for a few biological activities. Here, we propose a simple, fast, diastereoselective, and green synthesis of drynaran, using ethanol as solvent and 5-hydroxymethylfurfural as starting material.
Keywords:
Crossed aldol condensation; Diastereoselective reaction; Drinaria bonii; HMF; X-ray diffraction analysis

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