#7835. Hyaluronan degradation by reactive oxygen species: Scavenging effect of the hexahydropyridoindole stobadine and two of its derivatives

September 2026publication date
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Journal’s subject area:
Mechanical Engineering;
Materials Chemistry;
Mechanics of Materials;
Ceramics and Composites;
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Abstract:
The antioxidative effect of stobadine and two of its derivatives, SMe1EC2·HCl and SM1M3EC2·HCl, on the kinetics of degradation of high-molar-mass hyaluronan (HA) was tested in the oxidative system comprising Cu(II) plus ascorbic acid. Addition of stobadine at the initiation step of HA degradation resulted in a significant inhibition of degradation of the biopolymer. However, the protective effect of stobadine indicated dose-independent action.
Keywords:
ABTS assay; Cyclic voltammetry; DPPH assay; EPR spin trapping method; Free radicals; Hyaluronan degradation; Rotational viscometry; Stobadine; Stobadine derivatives

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