#7818. Organoids: a novel modality in disease modeling

September 2026publication date
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Journal’s subject area:
Medicine
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Abstract:
Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more accurately. Recent advances in the improvement of protocols have resulted in establishing three-dimensional (3D) organ-like architectures called ‘organoids’ that can display the characteristics of their corresponding real organs, including morphological features, functional activities, and personalized responses to specific pathogens. We discuss different organoid-based 3D models herein, which are classified based on their original germinal layer.
Keywords:
Disease modeling; Drug screening; Germ layer; Organoid

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