#7618. Quantitative label-free optical technique to analyze the ultrastructure changes and spatiotemporal relationship of enamel induced by Msx2 deletion

October 2026publication date
Proposal available till 23-05-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Engineering (all);
Physics and Astronomy (all);
Biochemistry, Genetics and Molecular Biology (all);
Chemistry (all);
Materials Science (all);
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Abstract:
New advances in the molecular mechanism of enamel mineralization reveal the practical significance of regenerative medicine in clinical transformation. Muscle segment homeobox 2 (MSX2), a transcription factor, is recently reported to be closely associated with the amelogenesis imperfecta (AI). To elucidate the biomineralization framework of AI enamel, herein, Msx2 gene mutant mice are investigated by dual-mode noninvasive spectroscopic analytical techniques for the first time.
Keywords:
amelogenesis imperfecta; enamel; MSX2; optical coherence tomography; Raman spectroscopy

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