#7615. Quantitative phase microscopy monitors subcellular dynamics in single cells exposed to nanosecond pulsed electric fields

October 2026publication date
Proposal available till 23-05-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Engineering (all);
Physics and Astronomy (all);
Biochemistry, Genetics and Molecular Biology (all);
Chemistry (all);
Materials Science (all);
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Abstract:
A substantial body of literature exists to study the dynamics of single cells exposed to short duration (<1 ?s), high peak power (~1 MV/m) transient electric fields. Much of this research is limited to traditional fluorescence-based microscopy techniques, which introduce exogenous agents to the culture and are only sensitive to a single molecular target. Quantitative phase imaging (QPI) is a coherent imaging modality which uses optical path length as a label-free contrast mechanism, and has proven highly effective for the study of single-cell dynamics.
Keywords:
directed energy; electric field biophysics; quantitative phase imaging

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