#7203. Cell–surface interactions on gold-coated polydimethylsiloxane nanocomposite structures: Localized laser heating on cell viability

January 2027publication date
Proposal available till 11-05-2025
4 total number of authors per manuscript0 $

The title of the journal is available only for the authors who have already paid for
Journal’s subject area:
Mechanical Engineering;
Mechanics of Materials;
Condensed Matter Physics;
Materials Science (all);
Places in the authors’ list:
place 1place 2place 3place 4
FreeFreeFreeFree
2510 $1340 $1170 $1000 $
Contract №7203.1 Contract №7203.2 Contract №7203.3 Contract №7203.4
1 place - free (for sale)
2 place - free (for sale)
3 place - free (for sale)
4 place - free (for sale)

Abstract:
This article presents the results of cell–surface interactions on polydimethylsiloxane (PDMS)-based substrates coated with nanoscale gold (Au) thin films. The surfaces of PDMS and PDMS–magnetite (MNP)-based substrates were treated with UV-ozone, prior to thermal vapor deposition (sputter-coated) of thin films of titanium (Ti) onto the substrates to improve the adhesion of Au coatings. The thin layer of Ti was thermally evaporated to improve interfacial adhesion, which was enhanced by a 40-nm thick film microwrinkled/buckled wavy layer of Au, that was coated to enhance cell–surface interactions and protein absorption. Cell–surface interactions were studied on the hybrid surfaces using a combination of optical and fluorescence microscopy. Consequently, cell proliferation and surface cytotoxicity (of the sputter-coated PDMS surfaces) were elucidated by characterizing the metabolic activity in the presence of breast cancer and normal breast cells. The photothermal conversion efficiency associated with laser–materials interactions with the PDMS/PDMS–magnetite-based composites was shown to have an optimum efficiency of ~31.8%. The implications of the results are discussed for potential applications of PDMS nanocomposites in implantable biomedical devices.
Keywords:
cell–surface interactions; implantable biomedical devices; laser–materials interactions; PDMS nanocomposites; photothermal conversion

Contacts :
0