#6688. Lamellar Level Correlations Between Mechanical Behavior and Composition in Mouse Bone

November 2026publication date
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Veterinary
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Abstract:
We studied the lamellar level correlations between the local composition and local mechanical properties in the femur of two inbred strains of mice (A/J and C57BL/6J (B6)), with known differences in the average mineralization and long-bone mechanical properties, to gain insights into how their extracellular matrix is mineralized. The local elastic moduli and indentation yield strengths were determined using spherical nanoindentation stress-strain analysis, while Raman spectroscopy was used to determine the local composition around the indents in a total of 11 samples.
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