#6391. Insight into the dust explosion hazard of pharmaceutical powders in the presence of flow aids

November 2026publication date
Proposal available till 22-05-2025
4 total number of authors per manuscript0 $

The title of the journal is available only for the authors who have already paid for
Journal’s subject area:
Food Science;
Management Science and Operations Research;
Safety, Risk, Reliability and Quality;
Industrial and Manufacturing Engineering;
Chemical Engineering (all);
Control and Systems Engineering;
Energy Engineering and Power Technology;
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Abstract:
Coating of nanoscale flow aids is widely used in pharmaceutical applications to increase the flowability of cohesive powders. For combustible pharmaceutical active ingredients and excipients, it is unclear whether increased flowability affects the dust explosion hazard. In this work, acetaminophen (APAP) and microcrystalline cellulose (MCC) were studied with and without a coating of silica nanoparticles. A full set of explosion parameters for the pure materials and their flow-improved mixtures was determined in accordance with ASTM standards.
Keywords:
Dust dispersibility; Dust explosion; Dust flowability; Pharmaceutical powders

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