#6261. Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli

August 2026publication date
Proposal available till 18-05-2025
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Journal’s subject area:
Applied Mathematics;
Modeling and Simulation;
Computer Science Applications;
Biochemistry, Genetics and Molecular Biology (all);
Drug Discovery;
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Abstract:
Biological functions of bacteria can be regulated by monitoring their own population density induced by the quorum sensing system. However, quantitative insight into the system’s dynamics and regulatory mechanism remain challenging. Here, we construct a comprehensive mathematical model of the synthetic quorum sensing circuit that controls population density in Escherichia coli. Simulations agree well with experimental results obtained under different ribosome-binding site (RBS) efficiencies. We present a quantitative description of the component dynamics and show how the components respond to isopropyl-?-D-1-thiogalactopyranoside (IPTG) induction. The optimal IPTG-induction range for efficiently controlling population density is quantified. The controllable area of population density by acyl-homoserine lactone (AHL) permeability is quantified as well, indicating that high AHL permeability should be treated with a high dose of IPTG, while low AHL permeability should be induced with low dose for efficiently controlling.
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