#6003. Boolean network modeling of ?-cell apoptosis and insulin resistance in type 2 diabetes mellitus

August 2026publication date
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Journal’s subject area:
Medicine
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Abstract:
Background: Major alteration in lifestyle of human population has promoted Type 2 diabetes mellitus (T2DM) to the level of an epidemic. This metabolic disorder is characterized by insulin resistance and pancreatic ?-cell dysfunction and apoptosis, triggered by endoplasmic reticulum (ER) stress, oxidative stress and cytokines. Computational modeling is necessary to consolidate information from various sources in order to obtain a comprehensive understanding of the pathogenesis of T2DM and to investigate possible interventions by performing in silico simulations.
Keywords:
Boolean model; Insulin resistance; Type 2 diabetes mellitus; ?-cell apoptosis

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