#5446. Computational analysis of high precision nano-sensors for diagnosis of viruses: Effects of partial antibody layer

August 2026publication date
Proposal available till 16-05-2025
4 total number of authors per manuscript0 $

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Journal’s subject area:
Numerical Analysis;
Applied Mathematics;
Computer Science (all);
Modeling and Simulation;
Theoretical Computer Science;
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Abstract:
By using these high precision nano-bio-sensors, the slightest mechanical changes are also recognizable, as its detection limit is one hundred times more than conventional methods such as electrochemical sensing. In this research, a silicon nano-bio-sensor is modeled based on a novel modified nonlocal Euler–Bernoulli beam theory. On this basis, shift of resonant frequencies are determined due to adsorption of fine biological particles on the antibody layer. In this regard, the effects of stiffness and mass of partial antibody layer in addition to surface tensions, nonlocal parameter and rotary inertia are investigated, simultaneously. Consequently, the precise resonant frequency of a cantilever biological nano-sensor is determined for diagnosis of viruses.
Keywords:
Antibody layer; Nano-bio-sensor; Nonlocal elasticity; Pathogenic agents; Resonant frequency; Rotary inertia; Surface tensions

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