#2206. Addendum to the Acknowledgments: Randomized and Observational Studies: Methodology Development

August 2026publication date
Proposal available till 30-05-2025
4 total number of authors per manuscript2520 $

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Journal’s subject area:
Sociology and Political Science;
Communication;
Economics and Econometrics;
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Abstract:
The necessity of including observational studies in meta-analyses has been discussed in the literature, but a synergistic analysis method for combining randomized and observational studies has not been reported. Observational studies differ in validity depending on the degree of the confounders influence. Combining interpretations may be challenging, especially if the statistical directions are similar but the magnitude of the pooled results are different between randomized and observational studies (the gray zone). Objective: To overcome these hindrances, in this study, we aim to introduce a logical method for clinical interpretation of randomized and observational studies. Methods: We designed a stepwise-hierarchical pooled analysis method to analyze both distribution trends and individual pooled results by dividing the included studies into at least three stages (eg, all studies, balanced studies, and randomized studies).
Keywords:
meta-analysis; observational study; randomized study; interpretation; combination; statistics; synergy; methodology; interpretation; hypothesis; validity

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