#11806. Erratum: Origins of N-formylmethamphetamine and N-acetylmethamphetamine in methamphetamine produced by the hydriodic acid and red phosphorus reduction of pseudoephedrine (Forensic Chemistry (20XX) 13, (S246817091830078X), (10.1016/j.forc.20XX.100158))

July 2026publication date
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Abstract:
N-Formylmethamphetamine (FMA) and N-acetylmethamphetamine (AMA) are suspected to be trace by-products in methamphetamine (MA) produced from pseudoephedrine using the Nagai reaction. However, these amides are not rational by-products of the Nagai reaction. FMA is an intermediate in the synthesis of MA using the Leuckart reaction. However, as there is the possibility that FMA is a by-product of the Nagai reaction, the significance of FMA as an indicator of the Leuckart reaction has been debated. AMA was also shown to be a by-product of the Nagai reaction, most likely due to reaction between MA and phenyl-2-propanone (P-2-P), itself a by-product of the Nagai reaction. Furthermore, during GC analysis of Nagai reaction products, MA has been shown to react with P-2-P or ethyl acetate in the injector to form AMA. Caution is recommended if the relative abundance of AMA and/or FMA are used as a basis for determining whether MA samples have a common source or not. Furthermore, it is clear that FMA cannot be considered to be a route-specific by-product for the Leuckart reaction – it is the abundance of FMA in a reaction mixture or profile, not simply its presence, that points to the involvement of the Leuckart reaction.
Keywords:
Nagai reaction; Leuckart reaction; N-acetylmethamphetamine;
N-formylmethamphetamine

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