#11803. Fe(II), Ni(II), Cu(II), and Co(II) salen Schiff base complexes: Proposal for a voltammetric sensor to analyze cocaine hydrochloride and its interferents

July 2026publication date
Proposal available till 20-05-2025
4 total number of authors per manuscript0 $

The title of the journal is available only for the authors who have already paid for
Journal’s subject area:
Materials Chemistry;
Analytical Chemistry;
Physical and Theoretical Chemistry;
Spectroscopy;
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More details about the manuscript: Science Citation Index Expanded or/and Social Sciences Citation Index
Abstract:
Given the fast-growing demand for anti-trafficking measures, this article investigates the development of voltammetric sensors for the oxidation of cocaine hydrochloride on the surface of carbon paste electrodes chemically modified with Schiff base complexes and their potential use for cocaine detection and quantification in seized samples. Voltammetric analyses revealed that [CoII(salen)] displayed amperometric and thermal stability, was uniformly distributed on the electrode surface, was only degraded at temperatures above 300 °C, and did not undergo passivation in acid medium. SIMCA chemometric analyses predicted the group belonging to cocaine hydrochloride and its interferents effectively, attesting to the good selectivity and specificity of the developed sensor. The sensor has potential application in forensic investigations: its LOD and LOQ, intra and inter-day precision, accuracy, linearity ranges, selectivity, specificity, and sensitivity are better as compared to other chemically modified electrodes. Finally, the Density Functional Theory (DFT) method confirmed the oxidation–reduction mechanisms proposed in the literature.
Keywords:
Chemically modified electrode; Chemometric analysis; Cocaine; Density functional theory; Schiff base complex; Voltammetric sensors

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