LogIn / RegistrationArticles for sale
- Head office address: Moscow, 123317, Moscow City, 8th Floor, Presnenskaya Embankment, 6, bldg. 2
- article@123mi.ru
- Сортировка:
- по горящим
- по цене
- по дате
#11424. Corrigendum to “Strategies for studying bone loss in microgravity” [REACH 17–20 (20XX) 100036] (REACH (20XX) 17–20, (S235230932030002X), (10.1016/j.reach.20XX.100036))
| August 2026 | publication date |
| Proposal available till | 19-05-2025 |
| 4 total number of authors per manuscript | 0 $ |
| The title of the journal is available only for the authors who have already paid for |
| Journal’s subject area: |
| Aerospace Engineering; Radiation; Radiology, Nuclear Medicine and Imaging; Human Factors and Ergonomics; Medicine (miscellaneous); |
| place 1 | place 2 | place 3 | place 4 |
| Free | Free | Free | Free |
| 2510 $ | 1340 $ | 1170 $ | 1000 $ |
Contract №11424.1   | Contract №11424.2 | Contract №11424.3 | Contract №11424.4 |
1 place - free (for sale)
2 place - free (for sale)
3 place - free (for sale)
4 place - free (for sale)
Abstract:
Astronauts are prone to a condition known as disuse osteoporosis as the microgravity environment negates the need for skeletal weight bearing. Several emerging technologies have paved the way for new research into the cellular and physiological mechanisms involved in disuse osteoporosis. In this review, we discuss the most impactful and current methodologies and technologies for both in vivo and in vitro studies of bone loss in space and with simulators on Earth from the past decade. We cover research performed on the International Space Station, uncrewed satellites, head-down tilt bed rest, rodent hindlimb unloading, and 2D/3D clinorotation for cell culture which are all established methods to mechanically unload the skeleton and/or bone cells. We also summarize the experimental findings documenting the changes that occur following exposure to unloading on a macroscopic scale, such as morphometric changes to the bone structure, and on the microscopic scale, such as effects on bone-forming osteoblasts, bone-resorbing osteoclasts, and mechanical stress-sensing osteocytes.
Keywords:
Bone health; Microgravity; Space physiology; Space biomedical technology; Gravitational biology; International space station; Simulated microgravity
Contacts :
2 place - free (for sale)
3 place - free (for sale)
4 place - free (for sale)
Abstract:
Astronauts are prone to a condition known as disuse osteoporosis as the microgravity environment negates the need for skeletal weight bearing. Several emerging technologies have paved the way for new research into the cellular and physiological mechanisms involved in disuse osteoporosis. In this review, we discuss the most impactful and current methodologies and technologies for both in vivo and in vitro studies of bone loss in space and with simulators on Earth from the past decade. We cover research performed on the International Space Station, uncrewed satellites, head-down tilt bed rest, rodent hindlimb unloading, and 2D/3D clinorotation for cell culture which are all established methods to mechanically unload the skeleton and/or bone cells. We also summarize the experimental findings documenting the changes that occur following exposure to unloading on a macroscopic scale, such as morphometric changes to the bone structure, and on the microscopic scale, such as effects on bone-forming osteoblasts, bone-resorbing osteoclasts, and mechanical stress-sensing osteocytes.
Keywords:
Bone health; Microgravity; Space physiology; Space biomedical technology; Gravitational biology; International space station; Simulated microgravity
Contacts :
