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#11370. Efficacy and safety of endoscopic retrograde cholangiopancreatography in the very elderly by using a combination of intravenous midazolam, ketamine and pethidine
| August 2026 | publication date |
| Proposal available till | 12-05-2025 |
| 4 total number of authors per manuscript | 0 $ |
| The title of the journal is available only for the authors who have already paid for |
| Journal’s subject area: |
| Health (social science); Gerontology; Geriatrics and Gerontology; |
| place 1 | place 2 | place 3 | place 4 |
| Free | Free | Free | Free |
| 2510 $ | 1340 $ | 1170 $ | 1000 $ |
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Abstract:
The number of therapeutic endoscopic procedures in elderly individuals keeps increasing and this population has a high risk of adverse events related to sedation and general anesthesia. However, there is a paucity on data about the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in this population. In total, 417 consecutive ERCP procedures were performed in 362 patients between September 20XX and January 20XX. The prevalence of comorbidities, use of anticoagulants and American Society of Anesthesiologists (ASA) physical status classification levels were significantly higher in Group A (P < 0.05). The incidence of periampullary diverticula, malignancy, rate of difficult cannulation, mean number of stones, use of biliary stents and stent dysfunction was also significantly higher in Group A (P < 0.05). The medication doses used were significantly higher and emergence symptoms were significantly more frequent in Group B (P < 0.05). The rates of bleeding, pancreatitis, perforation, cholangitis, hypoxia, hypotension and the length of hospital stay did not significantly differ between the two groups. ERCP can be safely performed in elderly patients using a combination of midazolam and ketamine without propofol.
Keywords:
deep sedation; elderly; ERCP; propofol
Contacts :
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Abstract:
The number of therapeutic endoscopic procedures in elderly individuals keeps increasing and this population has a high risk of adverse events related to sedation and general anesthesia. However, there is a paucity on data about the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in this population. In total, 417 consecutive ERCP procedures were performed in 362 patients between September 20XX and January 20XX. The prevalence of comorbidities, use of anticoagulants and American Society of Anesthesiologists (ASA) physical status classification levels were significantly higher in Group A (P < 0.05). The incidence of periampullary diverticula, malignancy, rate of difficult cannulation, mean number of stones, use of biliary stents and stent dysfunction was also significantly higher in Group A (P < 0.05). The medication doses used were significantly higher and emergence symptoms were significantly more frequent in Group B (P < 0.05). The rates of bleeding, pancreatitis, perforation, cholangitis, hypoxia, hypotension and the length of hospital stay did not significantly differ between the two groups. ERCP can be safely performed in elderly patients using a combination of midazolam and ketamine without propofol.
Keywords:
deep sedation; elderly; ERCP; propofol
Contacts :
