#11369. Low urine pH is a risk factor for low muscle mass: A new way to predict sarcopenia

July 2026publication date
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Journal’s subject area:
Health (social science);
Gerontology;
Geriatrics and Gerontology;
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Abstract:
Sarcopenia, one of the primary diseases of the older adult population, is a condition characterized by loss of skeletal muscle mass, strength and functionality. The goal of this cohort study was to examine the relationship between urine pH level and skeletal muscle mass. This community-based cross-sectional study was carried out among 9712 individuals (4992 men and 4720 women). Bioelectric impedance analysis was used to measure the percentage of skeletal muscle mass (PSMM). We collected first fasting morning urine samples after overnight fasting, and urine pH was measured with a dipstick. In the fully adjusted model, all-subject analysis showed a statistically significant association between urine pH and the PSMM with a β coefficient of 0.820 (95% CI 0.615–1.025; P < 0.001). Additionally, by-sex analysis showed that urine pH was related to the PSMM in both sexes, with ? coefficients of 0.261 (95% CI 0.006–0.516; P = 0.045) in men and 0.179 (95% CI 0.029–0.328; P = 0.019) in women. By-obesity status analysis showed that urine pH was related to the PSMM in the body mass index [removed] 0.05). The results showed the impacts of urine pH levels on skeletal muscle mass in both sexes and non-obese populations.
Keywords:
low muscle mass; sarcopenia; urine pH

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