#8643. Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans

January 2027publication date
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Journal’s subject area:
Agricultural and Biological Sciences (miscellaneous);
Materials Science (miscellaneous);
Biochemistry, Genetics and Molecular Biology (miscellaneous);
Physics and Astronomy (miscellaneous);
Medicine (miscellaneous);
Space and Planetary Science;
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Abstract:
Here, we evaluate the epigenetic regulation of gene expression in space-flown C. elegans by comparing wild type and histone deacetylase (hda)-4 mutants. The results indicate that under microgravity, C. elegans activates histone deacetylase HDA-4 to suppress overregulation of several genes, including the DUF-19 family. In other words, the expression of certain genes, including negative regulators of growth and development, is epigenetically fine-tuned to adapt to the space microgravity.
Keywords:
nematodes; epigenetic regulation; gene expression; microgravity

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